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5-HIAA, VMA & HVA in Urine Reagent Kit (RUO)
5-HIAA, VMA & HVA in Urine Reagent Kit (RUO)
The Diagnotix Catecholamine Metabolites Reagent Kit is designed for quantitative LC-MS/MS analysis of the metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and vanillylmandelic acid (VMA) in human urine.
The kit provides a complete reagent set for laboratories conducting research on neurotransmitter and catecholamine metabolites using UHPLC-MS/MS systems. Matrix-matched calibrators and stable isotope-labelled internal standards support reliable quantification and help compensate for matrix effects during analysis.
The assay features straightforward sample preparation and a robust workflow, allowing the method to be easily implemented on existing LC-MS/MS platforms. This makes the kit particularly suitable for laboratories seeking a standardised approach without the need to develop a complete LC-MS/MS method in-house.
Calibrators are assigned using multiple independent SKML external quality assessment samples.
The reagent kit is supplied as a Research Use Only laboratory product.
Technical data
| Repeatability (Simple Precision) (CV%) | Control I (low) |
|---|---|
| 5-HIAA: 1.6 % | |
| VMA: 2.0 % | |
| HVA: 1.8 % | |
| Control III (high) | |
| 5-HIAA: 0.7 % | |
| VMA: 1.2 % | |
| HVA: 1.5% | |
| Pooled sample: | |
| 5-HIAA: 1.1 % | |
| VMA: 1.6 % | |
| HVA: 2.2 % | |
| Reproducibility (Complex Precision) (CV%) | Control I (low) |
| 5-HIAA: 2.5 % | |
| VMA: 4.2 % | |
| HVA: 3.2 % | |
| Control III (high) | |
| 5-HIAA: 4.0 % | |
| VMA: 4.3 % | |
| HVA: 3.9 % | |
| Pooled sample: | |
| 5-HIAA: 7.8 % | |
| VMA: 8.5 % | |
| HVA: 6.1 % | |
| Limit of Quantification | 5-HIAA: 0.7 µmol/l |
| VMA: <0.29 µmol/l | |
| HVA: <0.24 µmol/l | |
| Linearity | 5-HIAA: 300 µmol/l |
| VMA: 300 µmol/l | |
| HVA: 300 µmol/l |
Important Notice: The information provided on this website alone is not sufficient for the correct and safe operation of this product. Always refer to the applicable Instructions for Use and accompanying documentation, including any warnings and safety notices.
Please note that system-specific conditions may influence results. If you have any questions or require technical support, we encourage you to contact us to discuss your specific setup or requirements.
For Research Use Only (RUO). Not for use in diagnostic procedures. Preparation for future IVDR registration is planned.
Included in this set
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Contact details
De Plassen 4
9902 SE Appingedam
The Netherlands
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