Intended Use

The Diagnotix Psychotropic Medication 1 LC-MS Reagent Kit is designed to determine the concentration of one or more of the listed analytes and metabolites in serum or plasma as a basis for further diagnostics.

Technical Benefits

1. Balanced panel: The most abundant compounds and their common metabolites are chosen to ensure that the panel is not too large, but still meets the challenges of routine use. The larger the panel, the more costs are involved to include all analytes and their isotopes, but also more trade-offs must be made for chromatographic optimization.
2. Unique panel: At the request of Dutch specialists, we have added E- and Z-OH nortriptyline to the panel.
3. Column and LC-MS friendly: A 40-fold deproteinization solution is used, which ensures extreme sample cleaning. Also, only a small injection volume is required for most systems.
4. Cost-effective and fast automatable sample preparation: No more SPE or LLE is needed. SPE for HPLC-UV analyses are used to extend the life of the column and reduce background noise from possible interfering drugs of abuse. As mentioned in 3. the sample is diluted 40 times and essentially all protein is removed. Furthermore, the use of LC-MS ensures that no co-eluting molecules interfere with your compound of interest, because they do not share the same mass transitions.

Why moving over from HPLC to LC-MS?

By switching to LC-MS, you immediately save on the use of SPE, longer sample preparation and therefore labor costs. In addition, the runtime of your method is extended and you do not have to worry about interfering other drugs, as long as they do not share the same mass transitions.

And because baseline separations are no longer necessary and the mobile phases do not have to contain high concentration buffers, you benefit from a much longer column life.

Especially interesting for laboratories that:

I. Have regular (large) batches of TCA patient samples and have a reliable automatable workflow.

II. Already have an LC-MS system, but still perform TDM or TCA analyses on HPLC-UV machines. Eliminating the use of your HPLC-UV system will immediately improve operational efficiency and reduce overall maintenance costs.

Contact Us for More Information

Interested in learning more about our Psychotropic Medication 1 solution for Tryciclic Antidepressants? Contact us via the contact form below. We looking forward to hear from you!