With 28 validated applications, the 4500MD proves its value as a robust and affordable LC-MS system for clinical diagnostics.


Sciex – globally recognised as a leading manufacturer of mass spectrometry instrumentation – recently published a new compendium centred around its 4500MD system. The document outlines 28 clinical LC-MS applications, covering toxicology, therapeutic drug monitoring (TDM), vitamin analysis, endocrinology, and small molecule biomarkers.


Compact, powerful, and clinically ready


The 4500MD is the smaller sibling of Sciex’s well-known 5500, 6500, Citrine, and 7500 platforms. Yet, despite its compact footprint, this entry-level model delivers impressive versatility and sensitivity. The compendium clearly demonstrates that the 4500MD can reliably handle the most requested clinical analytes.This shows that robust and cost-effective LC-MS for routine diagnostics is now more accessible than ever.


Fully compatible with Diagnotix methods


Among the highlighted applications, you’ll find several validated Diagnotix LC-MS kits, including:

Vitamin A & E
Vitamin B1 & B6
Methylmalonic Acid
Cortisol & Cortisone (both methods)
Plasma Metanephrines
Immunosuppressants
Psychotropic panels:
PS 1: Tricyclic antidepressants (TCA)
PS 2: Neuroleptics
PS 3: Antidepressants
Steroids Basic Panel

Our view: the best LC-MS choice for clinical labs today

At Diagnotix, we have extensive experience working with a wide range of LC-MS systems across multiple vendors and sensitivity levels. We understand what hospital labs truly need: a robust, versatile, and future-proof system that performs reliably for many years and supports as many applications as possible – all at an efficient cost.


Our hands-on experience now aligns with the evidence in this new compendium: the 4500MD is a true clinical workhorse – even at entry-level.


That’s why we believe the Sciex 4500MD is currently the best LC-MS system for clinical diagnostics.